p16-Rb Pathway Interactive Simulator
Adjust the regulatory components to see their effects on cell cycle control and cancer development
Regulatory Controls
Low (0)
50%
High (100)
Normal expression
Inactive (0)
30%
Active (100)
None (0)
0%
Severe (100)
Preset Scenarios
Pathway Status
p16
50%
Inhibiting CDK4/6CDK4/6
15%
Effectively inhibitedRb
ACTIVE
HypophosphorylatedE2F
INACTIVE
Suppressed by RbCurrent Interactions:
- p16 → CDK4/6 inhibition: ACTIVE
- CDK4/6 → Rb phosphorylation: BLOCKED
- Rb → E2F inhibition: ACTIVE
Cell Cycle Control
CONTROLLED
Normal cell cycle checkpoints are functioning properly.
Cancer Risk
LOW
Tumor suppressor pathways are functioning normally.
Clinical Relevance
Current pathway status represents normal cellular regulation with functional tumor suppressor mechanisms.